Isaiah 53:6 NKJV - "All we like sheep have gone astray; we have turned, every one, to his own way; and the Lord has laid on Him the iniquity of us all."
This has been one of those powerful passages that has had an impact on many lives over the years. Along with 2 Corinthians 5:21 and 1 Peter 2:24 this passage points to the substitutionary work of Christ on the cross by taking our sins upon His own body while He hung on Calvary's cross. Of course, we should not miss the fact that it was the Lord, the Father, who actually laid those sins on His Son. God the Father took the position of the High Priest and, placing His hands on the head of the Lamb, God confessed the sins of mankind onto His Son.
Jesus would bear these sins on Himself as if He was the sinner! Jesus, the holy and perfect Son of God was willing to be "made sin for us, He who knew no sin" 2 Corinthians 5:21. What was so foreign to Jesus was sinful failure! He had never disappointed His Father in the least, but now He was receiving from His Father the sins of the world and thus making Himself vulnerable to His Father's wrath. As we noted in 1 Peter 3:18, Jesus was "the Just for the unjust" dying in the place of the condemned sinner. He was the Substitute for all of us!
Remember in Genesis 22 when God ordered Abraham to bring his only son, Isaac, up to the mount to sacrifice him to God, that Abraham told his son that God would provide a "lamb". And Jesus was the Lamb provided for us!